CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.
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发表时间：
1994-12
期刊：
影响因子：
11.2
通讯作者：
M. Wainstein;Feng He;Daniel H. Robinson;H. Kung;Stuart Schwartz;Joseph M. Giaconia;N. Edgehouse;T. P. Pretlow;D. Bodner;E. Kursh;M. Resnick;A. Seftel;T. Pretlow
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作者：
M. Wainstein;Feng He;Daniel H. Robinson;H. Kung;Stuart Schwartz;Joseph M. Giaconia;N. Edgehouse;T. P. Pretlow;D. Bodner;E. Kursh;M. Resnick;A. Seftel;T. Pretlow
原发性人前列腺癌（PCA）在体内或体外的长期传播是罕见的。大多数此类PCA在表型上不同于人类中的大多数PCA;即，它们几乎不产生前列腺特异性抗原，并且对雄激素剥夺几乎没有反应。一种可连续移植的原发性人PCA，命名为CWR 22，表现出克隆性细胞遗传学畸变，导致裸鼠外周血中前列腺特异性抗原的高度升高，并且与其他异种移植物相比，对雄激素剥夺有异常反应。来自CWR 22的mRNA的研究已经证实了前列腺特异性抗原和表皮生长因子受体家族的表达，包括erbB 1/表皮生长因子受体、erbB 2/neu和erbB 3，但不表达erbB 4。这些受体的配体neu分化因子也表达。
The long-term propagation of primary human prostate cancer (PCA) in vivo or in vitro has been rare. Most such PCAs are phenotypically different from most PCAs in humans; i.e., they make little prostate specific antigen and respond little, if at all, to androgen deprivation. A serially transplantable, primary human PCA, designated CWR22, exhibits a clonal cytogenetic aberration, causes high elevations of prostate specific antigen in the peripheral blood of nude mice, and is unusually responsive to androgen deprivation as compared with other xenografts. Studies of mRNA from CWR22 have demonstrated the expression of prostate specific antigen and the epidermal growth factor receptor family including erbB1/epidermal growth factor receptor, erbB2/neu, and erbB3, but not erbB4. A ligand for these receptors, the neu differentiation factor, is also expressed.