Ultrasound measurements of pulse-wave velocity in the peripheral arteries of diabetic subjects.
Ultrasound measurements of pulse-wave velocity in the peripheral arteries of diabetic subjects.
复制标题
糖尿病受试者外周动脉脉搏波速度的超声测量。
DOI：
10.1042/cs0580053
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发表时间：
1980
期刊：
影响因子：
6
通讯作者：
J. D. Ward
中科院分区：
文献类型：
--
作者：
J. H. B. Scarpello;T. Martin;J. D. Ward
1.脉搏波速度在上肢和下肢已被测量在一系列糖尿病和对照组。受试者进行了研究，多普勒超声系统和实时频率分析仪。2.受试者包括三组：（a）伴有周围神经病变的糖尿病受试者（43）;（B）非并发症糖尿病受试者（8）;（c）非糖尿病对照受试者（11）。这些糖尿病患者周围神经病变包括12个非感染性足部溃疡，9个愈合的足部溃疡和22个没有足部溃疡的历史。所有的糖尿病患者和对照组患者的外周脉搏在临床上都是正常的。3.在上肢，所有组的脉搏波速度相似。相比之下，在下肢脉搏波速度显着增加（P <0.005）与对照组相比，非并发症糖尿病患者或糖尿病患者与周围神经病变单独愈合或溃疡的脚。4.这表明脉搏波速度的增加是由于潜在的、弥漫性的动脉粥样硬化。这在临床上无法检测到，并且发现主要影响下肢动脉而不是上肢血管。这可能是一个重要的病因学因素，在这些患者的足部溃疡的发展。
1. Pulse-wave velocity in both upper and lower limbs has been measured in a series of diabetic and control subjects. Subjects were studied with a Doppler ultrasound system and a real-time frequency analyser. 2. The subjects comprised three groups: (a) diabetic subjects with peripheral neuropathy (43); (b) non-complicated diabetic subjects (8); (c) non-diabetic control subjects (11). Those diabetic subjects with peripheral neuropathy included 12 with non-infected foot ulcers, nine with healed foot ulcers and 22 who gave no history of foot ulceration. All of the diabetic and control subjects had clinically normal peripheral pulses. 3. In the upper limbs the pulse-wave velocity was similar for all groups. By contrast, in the lower limbs pulse-wave velocity was significantly increased (P less than 0.005) in patients with healed or ulcerated feet compared with controls, non-complicated diabetic subjects or diabetic subjects with peripheral neuropathy alone. 4. It is suggested that the increased pulse-wave velocity results from an underlying, diffuse, atherosclerosis. This is not detectable clinically and was found to predominantly affect the lower limb arteries rather than the upper limb vessels. This may be an important aetiological factor in the development of foot ulcers in these patients.