Human immune repertoire in hepatitis B virus infection.

Human immune repertoire in hepatitis B virus infection.
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B型肝炎病毒感染中的人类免疫谱。

DOI:
10.3748/wjg.v27.i25.3790
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发表时间:
2021-07-07
影响因子:
4.3
通讯作者:
Zeng Z
Zeng Z
中科院分区:
医学2区
文献类型:
--
作者:
Zhan Q;Xu JH;Yu YY;Lo Kk E;Felicianna;El-Nezami H;Zeng Z

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乙肝病毒感染是一种公共健康威胁,影响着全球2.57亿人,并可发展为肝硬化、肝功能衰竭和肝细胞癌。乙肝病毒抗原诱导的获得性免疫反应在清除乙肝病毒中起着重要作用。免疫谱系测序(IRS)已被用于研究免疫系统背后的分子机制,寻找治疗乙肝病毒感染的新方法,并评估感染乙肝病毒或接种乙肝疫苗的个体的遗传反应和免疫特征。本文综述了人类免疫谱系分析方法,以及IRS在预测乙肝病毒感染进展、治疗和疫苗接种方面的应用。
Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.
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