Computational models of airway branching morphogenesis.
Computational models of airway branching morphogenesis.
复制标题
气道分支形态发生的计算模型。
DOI：
10.1016/j.semcdb.2016.06.003
复制
发表时间：
2017
影响因子：
7.3
通讯作者：
Nelson,CelesteM
中科院分区：
文献类型：
--
作者：
Varner,VictorD;Nelson,CelesteM
哺乳动物肺的支气管网络由数百万个二分分支组成，它们排列在一个高度复杂的、充满空间的树状结构中。最近肺分支形态发生的计算模型帮助揭示了构建这种分支结构的生物学机制。在这篇综述中，我们重点介绍了三种不同的理论方法——几何建模、反应扩散建模和连续力学建模——并讨论了这些模型如何共同确定建立有效支气管网络所需的几何原理，以及在发育中的胚胎中指定气道几何形状的图案机制。我们强调与生物实验相结合的模型，并提出计算模型的最新进展如何促进了我们对气道分支形态发生的理解。
The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture. In this review, we focus on three different theoretical approaches – geometric modeling, reaction-diffusion modeling, and continuum mechanical modeling – and discuss how, taken together, these models have identified the geometric principles necessary to build an efficient bronchial network, as well as the patterning mechanisms that specify airway geometry in the developing embryo. We emphasize models that are integrated with biological experiments and suggest how recent progress in computational modeling has advanced our understanding of airway branching morphogenesis.