Escape of intracellular Shigella from autophagy
Escape of intracellular Shigella from autophagy
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DOI：
10.1126/science.1106036
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发表时间：
2005-02-04
期刊：
影响因子：
56.9
通讯作者：
Sasakawa, C
中科院分区：
文献类型：
--
作者：
Ogawa, M;Yoshimori, T;Sasakawa, C
通过自噬降解不需要的细胞成分或细胞器，包括入侵微生物，对细胞存活至关重要。在这里，志贺氏菌，一种侵袭性细菌，被发现能够通过III型分泌系统分泌IcsB来逃避自噬。缺乏IcsB的突变菌在宿主细胞内增殖时被自噬捕获。IcsB不直接抑制自噬。相反，志贺氏菌VirG，一种细胞内肌动蛋白运动所需的蛋白质，通过与自噬蛋白Atg5结合诱导自噬。在非突变的志贺氏菌中，这种结合被IcsB与VirG的结合竞争性地抑制。
The degradation of undesirable cellular components or organelles, including invading microbes, by autophagy is crucial for cell survival. Here, Shigella, an invasive bacteria, was found to be able to escape autophagy by secreting IcsB by means of the type III secretion system. Mutant bacteria lacking IcsB were trapped by autophagy during multiplication within the host cells. IcsB did not directly inhibit autophagy. Rather, Shigella VirG, a protein required for intracellular actin-based motility, induced autophagy by binding to the autophagy protein, Atg5. In nonmutant Shigella, this binding is competitively inhibited by IcsB binding to VirG.