Interleukin-4 and breast cancer.
Interleukin-4 and breast cancer.
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DOI：
10.1007/bf02967457
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Toi, M
中科院分区：
文献类型：
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作者：
Nagai, S;Toi, M
IL-4是由T淋巴细胞产生的多效细胞因子，作用于多种细胞，例如T和B淋巴细胞、单核细胞、成纤维细胞、内皮细胞、巨噬细胞等。 IL-4 最初被描述为一种 B 细胞生长因子，现在已知可针对多种肿瘤（包括乳腺癌）提供有效的抗肿瘤活性。 IL-4 可诱导培养的乳腺癌细胞凋亡。此外，已明确IL-4在17β-HSD和3β-HSD等雌激素合成酶的调节中发挥着重要作用。这些发现表明，IL-4 不仅是 Th2 型免疫反应的关键酶，而且也是人类乳腺癌中肿瘤细胞生长本身的关键酶。
IL-4 is a pleiotropic cytokine produced by T lymphocytes which acts on various cells of such as T and B lymphocytes, monocytes, fibroblast, endothelial cells, macrophages and some others. IL-4 was originally described as a B cell growth factor, and now known to provide potent anti-tumor activity against various tumors, including breast cancer. IL-4 can induce apoptosis in cultured breast cancer cells. In addition, it has been clarified that IL-4 plays an important role in the regulation of estrogen synthesis enzymes including 17beta-HSD and 3beta-HSD. These findings imply that IL-4 is a key enzyme not only for Th2 type immune reactions but also for tumor cell growth itself in human breast cancer.