Development of histone deacetylase inhibitors as therapeutics for neurological disease.
Development of histone deacetylase inhibitors as therapeutics for neurological disease.
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DOI：
10.2217/fnl.09.55
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发表时间：
2009-11-01
期刊：
影响因子：
1.3
通讯作者：
Pandolfo M
中科院分区：
文献类型：
--
作者：
Gottesfeld JM;Pandolfo M
通过可逆乙酰化和/或甲基化对组蛋白和其他染色体蛋白的合成后修饰调节染色质动力学的许多方面，例如转录、复制和DNA修复。异常修饰状态与几种神经和神经运动疾病相关。因此，抑制或激活负责这些染色质修饰的酶的小分子作为潜在的人类治疗剂已经受到相当大的关注。本文综述了组蛋白去乙酰化酶抑制剂在神经系统疾病中的应用现状。
Postsynthetic modifications of histone and other chromosomal proteins by reversible acetylation and/or methylation regulate many aspects of chromatin dynamics, such as transcription, replication and DNA repair. Aberrant modification states are associated with several neurological and neuromotor diseases. Thus, small molecules that inhibit or activate the enzymes responsible for these chromatin modifications have received considerable attention as potential human therapeutics. This paper summarizes the current state of development of histone deacetylase inhibitors in a variety of neurological diseases.