Oxygen saturation measurements of the retinal vasculature in treated asymmetrical primary open-angle glaucoma using hyperspectral imaging
Oxygen saturation measurements of the retinal vasculature in treated asymmetrical primary open-angle glaucoma using hyperspectral imaging
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DOI：
10.1038/eye.2014.169
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发表时间：
2014-07
期刊：
影响因子：
3.9
通讯作者：
D. Mordant;I. Al-Abboud;G. Muyo;A. Gorman;A. R. Harvey;A. McNaught;A. McNaught
中科院分区：
文献类型：
--
作者：
D. Mordant;I. Al-Abboud;G. Muyo;A. Gorman;A. R. Harvey;A. McNaught;A. McNaught
目的探讨不对称原发性开角型青光眼（POAG）患者正常眼与治疗后眼视网膜血管氧饱和度测量值的差异。方法采用无创眼底高光谱相机，以2 nm为增量，在556 ~ 650 nm波段获取视网膜光谱图像。研究人员对11名接受POAG治疗的患者的14只正常眼睛和两只眼睛进行了成像和分析，使用的算法是利用血管光密度的光谱变化来估计视网膜血管内血液的氧饱和度。在治疗POAG组中，根据Humphrey视野分析仪结果的平均偏差，将每只眼睛分类为较晚期或较轻度青光眼。采用Welch校正的非配对t检验（双尾）比较正常受试者和治疗POAG亚组之间的平均血氧饱和度。结果治疗较晚和较晚的POAG眼的平均视网膜静脉氧饱和度（分别为48.2±21.6%和42.6±18.8%）显著高于正常眼（27.9±9.9%，P分别为0.03和0.01）。正常眼与治疗后POAG眼的动脉血氧饱和度无显著差异。结论治疗晚期POAG眼视网膜小静脉血氧饱和度升高可能表明视网膜内组织代谢耗氧量减少。
PurposeTo determine whether there are differences in retinal vascular oxygen saturation measurements, estimated using a hyperspectral fundus camera, between normal eyes and treated eyes of subjects with asymmetrical primary open-angle glaucoma (POAG).MethodsA noninvasive hyperspectral fundus camera was used to acquire spectral images of the retina at wavelengths between 556 and 650 nm in 2-nm increments. In total, 14 normal eyes and both eyes of 11 treated POAG subjects were imaged and analyzed using algorithms that use the spectral variation of the optical densities of blood vessels to estimate the oxygen saturation of blood within the retinal vasculature. In the treated POAG group, each of the eyes were categorized, based on the mean deviation of the Humphrey visual-field analyzer result, as either more-advanced or less-advanced, glaucomatous eyes. Unpaired t-tests (two-tailed) with Welch’s correction were used to compare the mean oxygen saturation between the normal subjects and the treated POAG subgroups.ResultsIn less-advanced and more-advanced-treated POAG eyes, mean retinal venular oxygen saturations (48.2±21.6% and 42.6±18.8%, respectively) were significantly higher than in normal eyes (27.9±9.9%; P= 0.03 and 0.01, respectively). Arteriolar oxygen saturation was not significantly different between normal eyes and treated POAG eyes.ConclusionsThe increased oxygen saturation of the retinal venules in advanced-treated POAG eyes may indicate reduced metabolic consumption of oxygen in the inner retinal tissues.