Association of ALDH2 Genotypes with Periodontitis Progression
Association of ALDH2 Genotypes with Periodontitis Progression
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DOI：
10.1177/0022034509356045
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发表时间：
2010-02-01
影响因子：
7.6
通讯作者：
Shizukuishi, S.
中科院分区：
文献类型：
--
作者：
Nishida, N.;Tanaka, M.;Shizukuishi, S.
牙周炎的进展可能受ALDH 2基因型的影响，其将乙醛氧化为乙酸盐，这导致乙醛在血浆中的积累和潜在的毒性作用。我们研究了ALDH 2基因型在饮酒和牙周病进展之间的酒精敏感性方面的前瞻性关联。在2003年，224（87.5%）的256个人在基线（1999年）检查完成了牙周袋深度测量的牙周炎进展的评估。排除了自报问卷和血液样本的缺失数据;因此，分析了183份样本。饮酒量>= 33.0 g/d的个体表现出较高的牙周病进展风险（OR = 3.54）。与ALDH 2 *1/*1个体相比，ALDH 2 *1/*2个体每天饮酒≥ 33 g/天显示牙周炎进展风险的显著优势比（OR = 4.28）。这些结果表明，饮酒以及酒精敏感性可能是牙周炎进展的危险因素。
The progression of periodontitis may be affected by ALDH2 genotypes with respect to the oxidation of acetaldehyde to acetate, which leads to the accumulation of acetaldehyde in plasma and potential toxic effects. We examined the prospective association of ALDH2 genotypes in terms of alcohol sensitivity between alcohol consumption and periodontal disease progression. In 2003, 224 of 256 (87.5%) individuals examined at baseline (1999) completed probing pocket depth measurements for the evaluation of periodontitis progression. Missing data on self-reported questionnaires and blood samples were excluded; therefore, 183 samples were analyzed. Individuals who consumed >= 33.0 g/day of alcohol exhibited high periodontal disease progression risk (OR = 3.54). ALDH2 *1/*2 individuals who consumed >= 33 g/day of alcohol displayed a significant odds ratio (OR = 4.28) of periodontitis progression risk, in contrast to ALDH2 *1/*1 individuals. These results suggested that alcohol consumption as well as alcohol sensitivity may be a risk factor for periodontitis progression.