Clinical characteristics of Japanese adults with growth hormone deficiency: a HypoCCS database study
Clinical characteristics of Japanese adults with growth hormone deficiency: a HypoCCS database study
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DOI：
10.1507/endocrj.k10e-363
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发表时间：
2011-05-01
影响因子：
2
通讯作者：
Chihara, Kazuo
中科院分区：
文献类型：
--
作者：
Shimatsu, Akira;Tai, Shigeru;Chihara, Kazuo
高加索成人生长激素（OH）缺乏症（GHD）的临床特征已得到很好的定义。然而，没有大规模的临床实践研究已经检查了日本成人GHD的临床特征。本研究的目的是通过回顾在低血糖控制和并发症研究（N = 349）中入组时未接受GH治疗的受试者的记录来描述日本成人GHD患者的临床特征。大多数参与者（349人中的280人; 80.2%）患有成人发作而不是儿童期发作的GHD。下丘脑-垂体瘤是日本成人GHD最常见的原因（247/349; 70.8%）;这些肿瘤主要是成人发作GHD参与者的垂体腺瘤（156/243; 64.2%）、生殖细胞肿瘤（19/40; 47.5%）和颅咽管瘤（18/40; 45.0%）。大多数参与者（310/349; 88.8%）有多种垂体激素缺乏症。血脂异常（195/349; 55.9%）、视野丧失（67/349; 19.2%）、高血压（59/349; 16.9%）和肝病（54/349; 15.5%）是日本GHD成人中最常见的既存疾病。与年龄和性别匹配的健康日本人相比，GHD参与者的生活质量在8个简短的36个领域中的7个领域中有所下降。我们的研究结果证实，日本成人GHD的临床特征与高加索成人GHD相似。这些临床特征的确认将提高临床医生识别和治疗日本成人GHD的能力。
The clinical characteristics of Caucasian adults with growth hormone (OH) deficiency (GHD) have been well defined. However, no large-scale clinical practice study has examined the clinical characteristics of Japanese adults with GHD. The aim of our study was to describe the clinical characteristics of Japanese adults with GHD by reviewing the records of participants who were GH-naive at the time of enrollment in the Hypopituitary Control and Complications Study (N = 349). The majority of participants (280 of 349; 80.2%) had adult-onset rather than childhood-onset GHD. Hypothalamo-pituitary tumors were the most common cause of GHD in Japanese adults (247 of 349; 70.8%); these tumors were primarily pituitary adenomas in participants with adult-onset GHD (156 of 243; 64.2%), and germ cell tumors (19 of 40; 47.5%) and craniopharyngiomas (18 of 40; 45.0%) in participants with childhood-onset GHD. Most participants (310 of 349; 88.8%) had multiple pituitary hormone deficiencies. Dyslipidemia (195 of 349; 55.9%), visual field loss (67 of 349; 19.2%), hypertension (59 of 349; 16.9%), and liver disease (54 of 349; 15.5%) were the most common pre-existing conditions in Japanese adults with GHD. Quality of life was decreased in seven of the eight short form-36 domains in participants with GHD compared with age-and sex-matched healthy Japanese individuals. Our findings confirm that the clinical characteristics of Japanese adults with GHD are similar to those of Caucasian adults with GHD. Confirmation of these clinical characteristics will enhance the ability of clinicians to identify and treat Japanese adults with GHD.