Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
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DOI：
10.1111/jcmm.16688
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发表时间：
2021-09
影响因子：
5.3
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Zhang L;Jiang X;Liu N;Li M;Kang J;Chen L;Tang J;Dong S;Lu F;Zhang W
Hydrogen sulphide (H2S) inhibits vascular smooth muscle cell (VSMC) proliferation induced by hyperglycaemia and hyperlipidaemia; however, the mechanisms are unclear. Here, we observed lower H2S levels and higher expression of the proliferation‐related proteins PCNA and cyclin D1 in db/db mouse aortae and vascular smooth muscle cells treated with 40 mmol/L glucose and 500 μmol/L palmitate, whereas exogenous H2S decreased PCNA and cyclin D1 expression. The nuclear translocation of mitochondrial pyruvate dehydrogenase complex‐E1 (PDC‐E1) was significantly increased in VSMCs treated with high glucose and palmitate, and it increased the level of acetyl‐CoA and histone acetylation (H3K9Ac). Exogenous H2S inhibited PDC‐E1 translocation from the mitochondria to the nucleus because PDC‐E1 was modified by S‐sulfhydration. In addition, PDC‐E1 was mutated at Cys101. Overexpression of PDC‐E1 mutated at Cys101 increased histone acetylation (H3K9Ac) and VSMC proliferation. Based on these findings, H2S regulated PDC‐E1 S‐sulfhydration at Cys101 to prevent its translocation from the mitochondria to the nucleus and to inhibit VSMC proliferation under diabetic conditions.
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影响因子：
--
作者：
Wang K;Deng X;Shen Z;Jia Y;Ding R;Li R;Liao X;Wang S;Ha Y;Kong Y;Wu Y;Guo J;Jie W
通讯作者：
Jie W
影响因子：
4.6
作者：
Kimura Y;Toyofuku Y;Koike S;Shibuya N;Nagahara N;Lefer D;Ogasawara Y;Kimura H
通讯作者：
Kimura H
影响因子：
64.5
作者：
Yi CH;Pan H;Seebacher J;Jang IH;Hyberts SG;Heffron GJ;Vander Heiden MG;Yang R;Li F;Locasale JW;Sharfi H;Zhai B;Rodriguez-Mias R;Luithardt H;Cantley LC;Daley GQ;Asara JM;Gygi SP;Wagner G;Liu CF;Yuan J
通讯作者：
Yuan J
影响因子：
16
作者：
Hitosugi, Taro;Fan, Jun;Chung, Tae-Wook;Lythgoe, Katherine;Wang, Xu;Xie, Jianxin;Ge, Qingyuan;Gu, Ting-Lei;Polakiewicz, Roberto D.;Roesel, Johannes L.;Chen, Georgia Z.;Boggon, Titus J.;Lonial, Sagar;Fu, Haian;Khuri, Fadlo R.;Kang, Sumin;Chen, Jing
通讯作者：
Chen, Jing
硫化氢通过 Nrf2-ROS-AMPK 信号通路降低高葡萄糖/棕榈酸酯诱导的内皮细胞自噬
影响因子：
7.5
作者：
Liu J;Wu J;Sun A;Sun Y;Yu X;Liu N;Dong S;Yang F;Zhang L;Zhong X;Xu C;Lu F;Zhang W
通讯作者：
Zhang W