Challenges in validating candidate therapeutic targets in cancer.
Challenges in validating candidate therapeutic targets in cancer.
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DOI：
10.7554/elife.32402
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发表时间：
2018-02-08
期刊：
影响因子：
7.7
通讯作者：
Hunter T
中科院分区：
文献类型：
--
作者：
Settleman J;Sawyers CL;Hunter T
More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly used to validate candidate therapeutic targets in cancer research.
