Expression of CD44 isoforms in cultured human trabecular meshwork cells.
Expression of CD44 isoforms in cultured human trabecular meshwork cells.
复制标题
CD44 同种型在培养的人小梁网细胞中的表达。
DOI：
10.1159/000055490
复制
发表时间：
1998
影响因子：
2.1
通讯作者：
Schwartz,DM
中科院分区：
文献类型：
--
作者：
Jumper,MD;Stern,R;Lui,GM;Formby,B;Schwartz,DM
Purpose:To determine the expression of CD44 isoforms in cultured human trabecular meshwork (HTM) and to discuss their possible relationship with outflow facility.Methods:CD44 isoform expression in cultured HTM was qualitatively examined using immunohistochemistry and RT-PCR analysis.Results:Immunohistochemistry of cultured HTM showed intense staining with a CD44s antibody, and with antibodies against CD44 exon 7, exon 11–12 and exon 14. By RT-PCR, at least three isoforms of CD44 were expressed in HTM: CD44s, CD44v-III and CD44v-I.Conclusions:At least three isoforms of CD44 are expressed in the HTM. CD44 may play a role in binding and turnover of hyaluronic acid in the trabecular meshwork, thereby regulating outflow facility.
