Cognitive, physiological, and personality correlates of recurrence of depression
Cognitive, physiological, and personality correlates of recurrence of depression
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DOI：
10.1016/j.jad.2005.04.001
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发表时间：
2005-08-01
影响因子：
6.6
通讯作者：
Ormel, J
中科院分区：
文献类型：
--
作者：
Bos, EH;Bouhuys, AL;Ormel, J
背景：抑郁症复发的风险很高，并且随着发作次数的增加而增加。我们调查了是否与复发性抑郁症的历史的个人偏离一个单一的情节，至于风险相关的变量在3个不同领域的抑郁research.Methods：参与者是102名门诊患者与重性抑郁症缓解发作（60复发，42 nonrecurrent）。我们评估了感知的情绪，从声音刺激，24小时尿游离皮质醇，和neuroticity.Results：复发组有较高的皮质醇水平比nonrecurrent组，和复发的妇女也有一个更消极的看法比nonrecurrent妇女。这些结果相互独立，也不能用神经质或残留症状来解释。性别差异被发现在所有3 domain.Limitations：横断面设计限制的可能性得出结论的因果关系观察effects.Conclusions：复发性抑郁症的缓解门诊患者偏离缓解门诊患者与单次发作抑郁症的生理和社会认知，在某种程度上，可能会增加他们的风险的发展，随后发作。这些结果可能对预防性治疗策略有影响。(c)2005 Elsevier B.V.保留所有权利。
Background: The risk of recurrence in depressive disorder is high and increases with the number of episodes. We investigated whether individuals with a history of recurrent depression deviate from individuals with a single episode, as regards risk-related variables in 3 different domains of depression research.Methods: Participants were 102 outpatients with major depressive disorder remitted from an episode (60 recurrent, 42 nonrecurrent). We assessed the perception of emotions from vocal stimuli, 24-h urinary free cortisol, and neuroticism.Results: The recurrent group had higher cortisol levels than the nonrecurrent group, and recurrent women also had a more negative perception than nonrecurrent women. These results were independent of each other, and could also not be accounted for by neuroticism or residual symptoms. Gender differences were found in all 3 domains.Limitations: The cross-sectional design limits the possibility to draw conclusions on the causality of the observed effects.Conclusions: Remitted outpatients with recurrent depression deviate from remitted outpatients with single episode depression as regards physiology and social cognition, in a way that may increase their risk of the development of subsequent episodes. The results may have implications for prophylactic treatment strategies. (c) 2005 Elsevier B.V. All rights reserved.