REGIONAL OBESITY AND RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY
REGIONAL OBESITY AND RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY
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DOI：
10.1016/0895-4356(91)90265-b
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发表时间：
1991-01-01
影响因子：
7.2
通讯作者：
HIGGINS, M
中科院分区：
文献类型：
--
作者：
KANNEL, WB;CUPPLES, LA;HIGGINS, M
心血管事件的风险是通过24年的监测来确定的，这些监测与通过相对体重反映的全身肥胖和通过皮褶和腰围/英寸高度估计的局部肥胖有关。 相对体重、肩胛下皮褶和腰围的上五分位值分别与男女心血管疾病风险增加相关。 总的心血管事件的风险随着区域性、中心性或腹部肥胖的程度而增加。 心血管疾病的死亡率也增加了。 相对体重增加和向心性肥胖都与胆固醇、血压、葡萄糖和尿酸等危险因素增加有关。 体重的变化反映了风险因素的变化，在15磅的体重波动范围内呈线性趋势。 肩胛下皮褶厚度和肩胛下与三头肌皮褶厚度之比，即中心性肥胖的测量指标，在两种性别中也特别与冠状动脉发作的可能性增加相关。 肩胛下皮褶对CHD风险的影响与体重指数（BMI）无关。 考虑所有危险因素的多变量分析表明，腹部肥胖对男性中风、心力衰竭、心血管和全因死亡率有独立影响。 在女性中，只有肩胛下肌与三头肌皮褶厚度的比例独立地导致CHD、心血管和所有原因的死亡率。 局部肥胖似乎是一个独立的贡献者心血管疾病在给定水平的一般肥胖，其影响只有部分介导的促进其他已知的危险因素。 这些数据表明，心血管疾病与腹部肥胖和全身肥胖密切相关。
Risk of cardiovascular events was determined over 24 years of surveillance in relation to general adiposity reflected by relative weight and by regional obesity estimated by skinfolds and waist girth per inch of height. Upper quintile values of relative weight, subscapular skinfolds and waist girth were each associated with increased risks of cardiovascular disease in both sexes. Risk of total cardiovascular events increased with the degree of regional, central or abdominal obesity. Mortality from cardiovascular disease was also increased. Increased relative weight and central obesity were both associated with increased risk factors including cholesterol, blood pressure, glucose and uric acid. Changes in weight were mirrored by changes in risk factors with linear trends over a 15 lb range of weight fluctuations. Subscapular skinfold and the ratio of subscapular-to-triceps skinfold, measures of central obesity, were in either sex also associated with an increased probability of coronary attacks in particular. The subscapular skinfold contributed to CHD risk independent of body mass index (BMI). Multivariate analyses taking all the risk factors into account indicate an independent effect of abdominal obesity on stroke, cardiac failure and cardiovascular and all-cause mortality in men. In women, only the subscapular-to-triceps skinfold ratio independently contributes to CHD, cardiovascular and all cause mortality. Regional obesity appears to be an independent contributor to cardiovascular disease at a given level of general adiposity, its effect only partially mediated through promotion of other known risk factors. These data suggest that cardiovascular disease is as closely linked to abdominal as to general adiposity.