FMRI of the prefrontal cortex during overt verbal fluency
FMRI of the prefrontal cortex during overt verbal fluency
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DOI：
10.1097/00001756-199701200-00036
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发表时间：
1997-01-20
期刊：
影响因子：
1.7
通讯作者：
Shulman, RG
中科院分区：
文献类型：
--
作者：
Phelps, EA;Hyder, F;Shulman, RG
众所周知，语言流畅性与左前额叶皮层的活动有关。最近的正电子发射断层扫描（PET）结果证实了这一发现。在本研究中，高分辨率功能磁共振成像（fMRI）被用来进一步定位与言语流畅性相关的前额皮质活动。在三个行为任务中观察到激活：（1）重复 - 受试者重复单词，（2）相反 - 受试者产生单词的反义词，以及（3）生成 - 受试者产生以给定字母开头的单词。当比较“Generate”与“Repeat”和“Opposite”时，我们观察到左侧额下回和前扣带回的小区域激活，类似于使用 PET 报告的质心。我们还发现额上沟周围有额外的激活。
VERBAL fluency is known to be associated with activity in the left prefrontal cortex. Recent positron emission tomography (PET) results confirmed this finding. In the present study, high resolution functional magnetic resonance imaging (fMRI) was used to further localize activity in the prefrontal cortex related to verbal fluency. Activation was observed in three behavioral tasks: (1) Repeat - subjects repeated words, (2) Opposite - subjects produced the antonym of words, and (3) Generate - subjects generated words beginning with a given letter. When comparing Generate with both Repeat and Opposite, we observed small areas of activation in the left inferior frontal gyrus and anterior cingulate, similar to the centers of mass reported using PET. We also found additional activation around the superior frontal sulcus.