New drugs for the treatment of Parkinson's disease
New drugs for the treatment of Parkinson's disease
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DOI：
10.1592/phco.20.2.26s.34631
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发表时间：
2000-01-01
期刊：
影响因子：
4.1
通讯作者：
LeWitt, PA
中科院分区：
文献类型：
--
作者：
LeWitt, PA
自从左旋多巴用于治疗帕金森病（PD）以来，已经有几种新的治疗方法旨在改善症状控制，在左旋多巴治疗几年后，症状控制可能会下降。多巴胺能药物可以作为左旋多巴的辅助剂或替代品。此外，一类新的药物，儿茶酚- o -甲基转移酶抑制剂，可以延长左旋多巴作用的持续时间。虽然手术选择如苍白球切开术提供了超越药物治疗领域的帕金森病改善，但明智的药物联合用药通常可以解决帕金森病的大多数问题。
Since the introduction of levodopa to treat Parkinson's disease (PD), several new therapies have been directed at improving symptom control, which can decline after a few years of levodopa therapy Dopaminergic agents can serve as adjuncts or as alternatives to levodopa. In addition, a new class of drugs, catechol-O-methyltransferase inhibitors, can extend the duration of levodopa action. Although surgical options such as pallidotomy offer improvement of parkinsonism beyond the realm of pharmacologic treatment, judicious administration of drugs in combination can generally solve most problems of PD.