7-T 1H MRS with adiabatic refocusing at short TE using radiofrequency focusing with a dual-channel volume transmit coil
7-T 1H MRS with adiabatic refocusing at short TE using radiofrequency focusing with a dual-channel volume transmit coil
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DOI：
10.1002/nbm.1641
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发表时间：
2011-11-01
影响因子：
2.9
通讯作者：
Klomp, D. W. J.
中科院分区：
文献类型：
--
作者：
Boer, V. O.;van Lier, A. L. H. M. W.;Klomp, D. W. J.
在体内，人脑超高场磁共振波谱能够以比目前临床上可能的更高的空间分辨率识别大量的代谢物。然而，由于再聚焦射频(RF)脉冲的低带宽，单体素光谱在超高场下的体内定位已被证明是具有挑战性的。到目前为止，所提出的在7T处定位MRS的方法受到长TE、固有信号损失和/或大的化学位移伪影的影响，该伪影导致共振之间的空间位移，并导致序列编辑效率降低。在这项工作中，我们证明了，通过驱动一个标准的音量线圈和两个射频放大器，将B-1(+)场聚焦在某个位置，并使用高带宽的绝热重聚焦脉冲，半激光(绝热选择性重聚焦半局部化)在人脑中是可行的，具有完全的信号采集和低化学位移伪像7 T。版权所有(C)2011 John Wiley&Sons，Ltd.
In vivo MRS of the human brain at ultrahigh field allows for the identification of a large number of metabolites at higher spatial resolutions than currently possible in clinical practice. However, the in vivo localization of single-voxel spectroscopy has been shown to be challenging at ultrahigh field because of the low bandwidth of refocusing radiofrequency (RF) pulses. Thus far, the proposed methods for localized MRS at 7 T suffer from long TE, inherent signal loss and/or a large chemical shift displacement artifact that causes a spatial displacement between resonances, and results in a decreased efficiency in editing sequences. In this work, we show that, by driving a standard volume coil with two RF amplifiers, focusing the B-1(+) field in a certain location and using high-bandwidth adiabatic refocusing pulses, a semi-LASER (semi-localized by adiabatic selective refocusing) localization is feasible at short TE in the human brain with full signal acquisition and a low chemical shift displacement artifact at 7 T. Copyright (C) 2011 John Wiley & Sons, Ltd.