DIFFERENTIAL-EFFECTS OF AMPHETAMINE AND NEUROLEPTICS ON NEGATIVE VS POSITIVE SYMPTOMS IN SCHIZOPHRENIA
DIFFERENTIAL-EFFECTS OF AMPHETAMINE AND NEUROLEPTICS ON NEGATIVE VS POSITIVE SYMPTOMS IN SCHIZOPHRENIA
复制标题
DOI：
10.1007/bf00433802
复制
发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
GERSHON, S
中科院分区：
文献类型：
--
作者：
ANGRIST, B;ROTROSEN, J;GERSHON, S
精神分裂症的阳性症状被精神抑制剂[氟哌啶醇]减少，被安非他明增加，占总简明精神病评定量表（BPRS）中观察到的变化的大部分。在相同的受试者中，阴性症状不受精神抑制剂的影响，但在安非他明后增加到一个刚刚达到统计学显著性的程度。这一增加是由于1项（情绪退缩）的阴性症状因素，这对精神抑制剂和安非他明的阳性症状。关于多巴胺在精神分裂症中的作用的新观点进行了讨论。
Positive symptoms of schizophrenia were diminished by neuroleptics [haloperdol] and increased by amphetamine and accounted for most of the change seen in the total Brief Psychiatric Rating Scale (BPRS). Negative symptoms in the same subjects were not affected by neuroleptics but increased after amphetamines to a degree that just attained statistical significance. This increase was due to 1 item (emotional withdrawal) of the negative symptom factor which responded to neuroleptics and amphetamines as did positive symptoms. New ideas about the role of dopamine in schizophrenia are discussed.