Exercise against lower body negative pressure as a countermeasure for cardiovascular and musculoskeletal deconditioning.
Exercise against lower body negative pressure as a countermeasure for cardiovascular and musculoskeletal deconditioning.
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对抗下半身负压的锻炼可以作为心血管和肌肉骨骼功能失调的对策。
DOI：
10.1016/0094-5765(94)90112-0
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发表时间：
1994
影响因子：
3.5
通讯作者：
A. Hargens
中科院分区：
文献类型：
--
作者：
G. Murthy;D. Watenpaugh;R. Ballard;A. Hargens
暴露于下体负压（LBNP）与口服盐和水的摄入已被宇航员测试作为一种对策，以防止飞行后立位不耐受。运动是宇航员在太空飞行中经常使用的另一种对策，以保持肌肉骨骼力量。我们假设，一种新的组合运动和同时暴露于下半身的负压在太空飞行将产生类似地球的肌肉骨骼负荷以及心血管刺激，以保持适应地球的重力。最近的研究结果表明，与直立姿势的类似腿部运动相比，以水平仰卧姿势在LBNP室内对抗100 mmHg LBNP的吸力进行腿部运动会产生同等（如果不是更大）的运动应力（没有LBNP）对抗地球引力。12因此，LBNP结合锻炼的概念可以证明是一种低成本和低质量的技术，以同时对心血管和肌肉骨骼系统施加压力。
Exposure to lower body negative pressure (LBNP) with oral salt and water ingestion has been tested by astronauts as a countermeasure to prevent postflight orthostatic intolerance. Exercise is another countermeasure that astronauts commonly use during spaceflight to maintain musculoskeletal strength. We hypothesize that a novel combination of exercise and simultaneous exposure to lower body negative pressure during spaceflight will produce Earth-like musculoskeletal loads as well as cardiovascular stimuli to maintain adaptation to Earth's gravity. Results from recent studies indicate that leg exercise within a LBNP chamber against the suction force of 100 mmHg LBNP in horizontal-supine posture produces an equivalent, if not greater exercise stress compared to similar leg exercise in upright posture (without LBNP) against Earth's gravity.12Therefore, the concept of LBNP combined with exercise may prove to be a low cost and low mass technique to stress the cardiovascular and the musculoskeletal systems simultaneously.