Task-dependency of the neural correlates of episodic encoding as measured by fMRI
Task-dependency of the neural correlates of episodic encoding as measured by fMRI
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DOI：
10.1093/cercor/11.12.1150
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发表时间：
2001-12-01
期刊：
影响因子：
3.7
通讯作者：
Rugg, MD
中科院分区：
文献类型：
--
作者：
Otten, LJ;Rugg, MD
使用事件相关的功能磁共振成像（fMRI），可以根据在随后的记忆测试中是否记住或忘记了项目，通过对比研究任务中引发的项目相关活动来研究记忆编码的神经相关性。先前使用这种方法的研究表明，当研究任务本质上是语义时，左前额叶皮层成功地将言语材料编码成情景记忆。在当前的研究中，我们询问情景编码的神经相关性是否因研究任务的类型而异。十七名志愿者参加了一项与事件相关的功能磁共振成像实验，在研究中，志愿者被提示对单词做出生命力或音节判断。在延迟了大约 15 分钟后进行了识别记忆测试。对于生命力任务，随后记住的单词在左侧和内侧前额叶区域表现出更大的激活。相比之下，对于音节任务，单词的成功记忆与双侧顶内沟、双侧梭状回旋、右侧前额叶皮层和左侧枕上回的激活有关。这些发现表明，支持情景编码的大脑网络根据研究任务的不同而有所不同。
Using event-related functional magnetic resonance imaging (fMRI), the neural correlates of memory encoding can be studied by contrasting item-related activity elicited in a study task according to whether the items are remembered or forgotten in a subsequent memory test. Previous studies using this approach have implicated the left prefrontal cortex in the successful encoding of verbal material into episodic memory when the study task is semantic in nature. In the current study, we asked whether the neural correlates of episodic encoding differ depending on type of study task. Seventeen volunteers participated in an event-related fMRI experiment in which at study, volunteers were cued to make either animacy or syllable judgements about words. A recognition memory test followed after a delay of similar to 15 min. For the animacy task, words that were subsequently remembered showed greater activation in left and medial prefrontal regions. For the syllable task, by contrast, successful memory for words was associated with activations in bilateral intraparietal sulcus, bilateral fusiform gyros, right prefrontal cortex and left superior occipital gyrus. These findings suggest that the brain networks supporting episodic encoding differ according to study task.