Pathogenicity of three isolates of porcine respiratory coronavirus in the USA
Pathogenicity of three isolates of porcine respiratory coronavirus in the USA
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DOI：
10.1136/vr.152.12.358
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发表时间：
2003-03-22
影响因子：
2.2
通讯作者：
Paul, PS
中科院分区：
文献类型：
--
作者：
Halbur, PG;Pallarés, FJ;Paul, PS
对来自美国的3株猪呼吸道冠状病毒（AR 310、LEPP和1894）进行了致病性研究。接种1894的猪在接种后4 ~ 10天发生轻度呼吸道疾病，接种AR 310和LEPP的猪在接种后4 ~ 10天发生中度呼吸道疾病，但所有猪在接种后14天完全恢复。接种后4 - 10天，肉眼和显微镜检查显示轻度（1894）至中度（AR 310和LEPP）多灶性支气管间质性肺炎。病变的特征是坏死性细支气管炎、单核细胞的间隔浸润和混合性肺泡渗出物。在未接种的对照猪中未观察到临床体征或显微镜病变。
The pathogenicity of three isolates of porcine respiratory coronavirus (AR310, LEPP and 1894) from the USA was assessed in specific pathogen-free pigs. Pigs inoculated with 1894 developed mild respiratory disease and pigs inoculated with AR310 and LEPP developed moderate respiratory disease from four to 10 days after they were inoculated, but all the pigs recovered fully by 14 days after inoculation. Gross and microscopic examination revealed mild (1894) to moderate (AR310 and LEPP) multifocal bronchointerstitial pneumonia from four to 10 days after inoculation. The lesions were characterised by necrotising bronchiolitis, septal infiltration with mononuclear cells, and a mixed alveolar exudate. No clinical signs or microscopic lesions were observed in control pigs that had not been inoculated.