Mechanical properties of the aneurysmal aorta
Mechanical properties of the aneurysmal aorta
复制标题
动脉瘤主动脉的机械特性
DOI：
10.1002/bjs.1800800540
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发表时间：
1993
影响因子：
9.6
通讯作者：
J. Powell
中科院分区：
文献类型：
--
作者：
F. Hinson;S. Macsweeney;J. Powell
对30例主动脉瘤和12例外周动脉疾病患者的腹主动脉进行了无创性力学性能研究。使用M型超声测量主动脉的扩张性，允许无创评估压力-应变弹性模量或主动脉刚度Ep。中位Ep值从对照受试者30岁时的4.0 N/cm 2（n = 10）增加到中年时的10.4 N/cm 2（n = 11）和老年人的14.0 N/cm 2（n = 13）。在存在正常直径的情况下，外周动脉疾病伴主动脉粥样硬化对主动脉僵硬度的影响很小，Ep中位数为16.0 N/cm 2。动脉瘤扩张与主动脉僵硬度显著增加相关，Ep中位数为31.3 N/cm 2（P < 0.001）。对于直径正常的动脉瘤，Ep在所有年龄段均依赖于平均动脉压。在主动脉瘤患者中，Ep与平均动脉压或主动脉直径之间没有明确的关系。在研究的患者中，15例接受了主动脉重建术;主动脉僵硬度（log Ep）的增加与主动脉活检中内侧弹性蛋白含量的减少有关（r =-0.63，P < 0.02）。这项研究表明，扩张或扩张血管的明显僵硬或无弹性，其中部分可归因于弹性蛋白的损失。
The mechanical properties of the abdominal aorta were investigated non-invasively in 30 patients with aortic anaeurysm and II with peripheral arterial disease. The distensibility of the aorta was measured using M-mode ultrasonography, permitting non-invasive assessment of the pressure-strain elastic modulus or aortic stiffness, Ep. The median Ep value increased, from 4.0 N/cm2 in control subjects in their third decade of life ( n = 10) to 10.4 N/cm2 in middle age ( n = 11) to 14.0 N/cm2 in the elderly (n = 13). In the presence of a normal diameter.peripheral arterial disease with aortic atherosclerosis had little effect on aortic stiffness, median Ep being 16.0 N/cm2. Aneurysmal dilatation was associated with a significant increase in aortic stiffness, median Ep being 31.3 N/cm2 ( P < 0.001). For aortas of normal diameter, Ep was at all ages dependent on mean arterial pressure. In patients with aortic aneurysms there was no clear relationship between Ep and mean arterial pressure or aortic diameter. Of the patients studied, 15 underwent aortic rcconstruction; increasing aortic stiffness (log Ep) was associated with a decreased medial elastin content of the aortic biopsy ( r = −0.63, P < 0.02 ). This study demonstrates the marked stiffness or inelasticity of dilated or aneurysmal vessels, part of which is attributable to the loss of elastin.