A randomized clinical trial of alternative stress management interventions in persons with HIV infection
A randomized clinical trial of alternative stress management interventions in persons with HIV infection
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DOI：
10.1037/0022-006x.76.3.431
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发表时间：
2008-06-01
影响因子：
5.9
通讯作者：
Ketchum, Jessica McKinney
中科院分区：
文献类型：
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作者：
McCain, Nancy L.;Gray, D. Patricia;Ketchum, Jessica McKinney
心理神经免疫学的研究表明，与感知压力相关的免疫抑制可能有助于HIV感染者的疾病进展。虽然压力管理干预可能会增强免疫功能，但很少有替代方法经过测试。这项随机临床试验是为了测试三种为期10周的压力管理方法的效果-认知行为放松训练（RLXN），专注太极训练（TCHI）和精神成长团体（SPRT）-与252名HIV感染者中的等待对照组（CTRL）相比。使用重复测量混合模型，作者发现，与CTRL组相比，（a）RLXN和TCHI组使用较少的情绪集中应对，（B）所有治疗组均增强了淋巴细胞增殖功能。尽管干预措施对心理社会功能的影响不大，但免疫功能改善的有力发现具有重要的临床意义，特别是对免疫介导疾病患者。
Research in psychoneuroimmunology suggests that immunosuppression associated with perceived stress may contribute to disease progression in persons with HIV infection. While stress management interventions may enhance immune function, few alternative approaches have yet been tested. This randomized clinical trial was conducted to test effects of three 10-week stress management approaches-cognitive-behavioral relaxation training (RLXN), focused tai chi training (TCHI), and spiritual growth groups (SPRT)-in comparison to a wait-listed control group (CTRL) among 252 individuals with HIV infection. Using repeated measures mixed modeling, the authors found that in comparison to the CTRL group, (a) both the RLXN and TCHI groups used less emotion-focused coping, and (b) all treatment groups had augmented lymphocyte proliferative function. Despite modest effects of the interventions on psychosocial functioning, robust findings of improved immune function have important clinical implications, particularly for persons with immune-mediated illnesses.