Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor.
Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor.
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通过靶标衍生的神经营养因子减少体内自然发生的运动神经元死亡。
DOI：
10.1126/science.3363373
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Appel,SH
中科院分区：
文献类型：
--
作者：
Oppenheim,RW;Haverkamp,LJ;Prevette,D;McManaman,JL;Appel,SH
在正常细胞死亡期（第5至10天），用胚胎后肢（第8至9天）的粗提物和部分纯化的提取物处理卵内鸡胚，可挽救大量运动神经元免于变性。部分纯化的提取物的存活活性是剂量依赖性和发育调节。感觉、交感、副交感和胆碱能交感节前神经元的存活不受后肢提取物治疗的影响。早期目标（后肢）去除后发生的大量运动神经元死亡通过每日用后肢提取物治疗而部分改善。这些结果表明，靶源性神经营养因子参与运动神经元存活的调节。
Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5 to 10) rescues a significant number of motoneurons from degeneration. The survival activity of partially purified extract was dose-dependent and developmentally regulated. The survival of sensory, sympathetic, parasympathetic, and a population of cholinergic sympathetic preganglionic neurons was unaffected by treatment with hindlimb extract. The massive motoneuron death that occurs after early target (hindlimb) removal was partially ameliorated by daily treatment with the hindlimb extract. These results indicate that a target-derived neurotrophic factor is involved in the regulation of motoneuron survival in vivo.