PRENATAL EXPOSURE TO MORPHINE IN MICE - ENHANCED RESPONSIVENESS TO MORPHINE AND STRESS
PRENATAL EXPOSURE TO MORPHINE IN MICE - ENHANCED RESPONSIVENESS TO MORPHINE AND STRESS
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DOI：
10.1016/0091-3057(84)90138-2
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
AMMASSARITEULE, M
中科院分区：
文献类型：
--
作者：
CASTELLANO, C;AMMASSARITEULE, M
本实验研究了妊娠前给予吗啡对CD_1小鼠行为的影响。进行了两组实验。在第一组，这是在发展过程中进行的;产后反射的措施，发现只有一个轻微的赤字，在涉及运动控制的测试和活动措施表明，自发活动的显着减少，这是明显的，只有在过程中的第一个产后天。在第二组实验中，对成年小鼠的活动、镇痛和被动回避学习进行了测试;在产前暴露于盐水的小鼠和预先暴露于吗啡的小鼠的表现之间的基线条件下没有观察到差异。与对照组相比，增强吗啡管理（活动和被动回避措施），吗啡和应激（镇痛措施）的反应被发现。
Some behavioral effects of prenatal morphine administration were studied in CD1 mice. Two sets of experiments were carried out. In a 1st set, which was performed during development; measures of postnatal reflexes revealed only a light deficit in tests involving motor control; and activity measures showed a significant reduction of spontaneous activity which was evident only in the course of the 1st postnatal days. In a 2nd set of experiments, in which adult mice were tested for activity, analgesia and passive avoidance learning; no difference was observed in baseline conditions between the performances of the mice prenatally exposed to saline and those preexposed to morphine. Compared with controls, enhanced responsiveness to morphine administration (for the activity and passive avoidance measures), and to morphine and stress (for the analgesic measures) were found.