Signet Ring Cell Carcinoma of Resectable Metastatic Colorectal Cancer Has Rare Surgical Value
Signet Ring Cell Carcinoma of Resectable Metastatic Colorectal Cancer Has Rare Surgical Value
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DOI：
10.1002/jso.24437
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发表时间：
2016-12-15
影响因子：
2.5
通讯作者：
Du, Jinlin
中科院分区：
文献类型：
--
作者：
Fu, Jianfei;Wu, Lunpo;Du, Jinlin
背景和目的：印戒细胞癌（SRCC）是转移性结直肠癌（mCRC）中一个独特的亚群。目的是探讨切除转移性印戒细胞结直肠癌患者的价值。方法：回顾性分析1998-2010年监测、流行病学和最终结果数据库中接受切除术的mCRC患者。采用Kaplan-Meier和COX模型分析生存率差异。采用Logistic回归模型评价SRCC与其他临床病理因素的关系。结果：3568例患者中，94例（2.63%）发生SRCC。SRCC和非SRCC患者的中位生存时间分别为17个月和29个月（P < 0.001）。多因素分析表明，小细胞癌是总生存差的独立预后因素。基于单因素分析确定的变量的Logistic回归模型表明，年龄越小(
Background and Objectives: Signet ring cell carcinoma (SRCC) is a uniquely separated subgroup in metastatic colorectal cancer (mCRC). The aims are to investigate the value of resection in patients with resectable metastatic signet ring cell colorectal cancer.Methods: Patients with mCRC who underwent resection in Surveillance, Epidemiology, and End Results database during 1998-2010 were retrospectively analyzed. Kaplan-Meier and COX models were used to analyze the differences in the survival. Logistic regression models were used to evaluate the relationship between SRCC and other clinicopathological factors.Results: Among the 3,568 patients, 94 (2.63%) patients had SRCC. The median survival time of patients with SRCC and non-SRCC were 17 and 29 months, respectively (P < 0.001). Multivariate analysis indicated that SRCC was an independent prognostic factor for poor overall survival. Logistic regression model based on variables identified by univariate analysis indicated that younger age (