Molecular Genetics of Pancreatic Neoplasms.
Molecular Genetics of Pancreatic Neoplasms.
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DOI：
10.1016/j.path.2016.05.011
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发表时间：
2016-12-01
影响因子：
--
通讯作者：
Wood, Laura D
中科院分区：
文献类型：
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作者：
Hosoda, Waki;Wood, Laura D
胰腺肿瘤具有广泛的组织学类型和不同的临床结果。高通量测序技术的最新进展极大地加深了我们对胰腺肿瘤的理解。现在，胰腺肿瘤的主要组织学类型的外显子组已经被测序，它们的遗传景观已经被揭示。本文综述了胰腺肿瘤潜在的分子变化，特别是胰腺肿瘤组织学类型的遗传变化。重点介绍了具有潜在治疗靶点的关键基因的分子特征。
Pancreatic neoplasms have a wide range ofhistologic types with distinct clinical outcomes. Recent advances in high-throughput sequencing technologies have greatly deepened our understanding of pancreatic neoplasms. Now, the exomes of major histologic types of pancreatic neoplasms have been sequenced, and their genetic landscapes have been revealed. This article reviews the molecular changes underlying pancreatic neoplasms, with a special focus on the genetic changes that characterize the histologic types of pancreatic neoplasms. Emphasis is also made on the molecular features of key genes that have the potential for therapeutic targets.