EFFECTS OF AN ADENOSINE-RECEPTOR ANTAGONIST ON INSULIN-RESISTANCE IN SOLEUS MUSCLE FROM OBESE ZUCKER RATS
EFFECTS OF AN ADENOSINE-RECEPTOR ANTAGONIST ON INSULIN-RESISTANCE IN SOLEUS MUSCLE FROM OBESE ZUCKER RATS
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DOI：
10.1042/bj2210915
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发表时间：
1984-01-01
影响因子：
4.1
通讯作者：
NEWSHOLME, EA
中科院分区：
文献类型：
--
作者：
CHALLIS, RAJ;BUDOHOSKI, L;NEWSHOLME, EA
糖酵解对胰岛素的敏感性降低，从遗传性肥胖Zucker大鼠孤立的比目鱼肌中看到的被取消的腺苷受体拮抗剂8-苯基茶碱的孵育介质中，8-苯基茶碱没有影响糖原合成对胰岛素的敏感性。遗传性肥胖大鼠肌肉葡萄糖利用敏感性的变化可以部分解释为骨骼肌中腺苷浓度或腺苷受体亲和力的改变。
The decreased sensitivity of glycolysis to insulin seen in isolated soleus muscles from genetically obese Zucker rats was abolished by addition of the adenosine-receptor antagonist 8-phenyltheophylline to the incubation medium; 8-phenyltheophylline had no effect on the sensitivity of glycogen synthesis to insulin. Changes in the sensitivity of glucose utilization by muscles of genetically obese rats may be explained, in part, by a modification in either the concentration of adenosine or the affinity of adenosine receptors in skeletal muscle.