Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover
Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover
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DOI：
10.1073/pnas.1004433107
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发表时间：
2010-06-29
影响因子：
11.1
通讯作者：
Si, Kausik
中科院分区：
文献类型：
--
作者：
Mastushita-Sakai, Tomoko;White-Grindley, Erica;Si, Kausik
在长期记忆的研究中，记忆如何持续是一个基本且尚未解决的问题。持久记忆痕迹的分子成分是什么？先前对海兔和果蝇的研究发现，具有自我延续的朊病毒样特性的RNA结合蛋白的神经元变体，即细胞质多腺苷酸化元件结合蛋白，是蜗牛长期突触促进和果蝇长期记忆持续存在所必需的。在这项研究中，我们鉴定了果蝇神经元细胞质多聚腺苷酸化元件结合蛋白 Orb2 的 mRNA 靶标。这些 Orb2 靶标包括参与神经元生长、突触形成和有趣的蛋白质周转的基因。这些目标表明，记忆痕迹的持久形式可能由维持激活突触中突触生长持续、宽松环境的分子组成。
In the study of long-term memory, how memory persists is a fundamental and unresolved question. What are the molecular components of the long-lasting memory trace? Previous studies in Aplysia and Drosophila have found that a neuronal variant of a RNA-binding protein with a self-perpetuating prion-like property, cytoplasmic polyadenylation element binding protein, is required for the persistence of long-term synaptic facilitation in the snail and long-term memory in the fly. In this study, we have identified the mRNA targets of the Drosophila neuronal cytoplasmic polyadenylation element binding protein, Orb2. These Orb2 targets include genes involved in neuronal growth, synapse formation, and intriguingly, protein turnover. These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse.