KINETOCHORES, MICROTUBULES AND THE METAPHASE CHECKPOINT
KINETOCHORES, MICROTUBULES AND THE METAPHASE CHECKPOINT
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DOI：
10.1016/s0962-8924(00)88968-0
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发表时间：
1995-04-01
影响因子：
19
通讯作者：
GORBSKY, GJ
中科院分区：
文献类型：
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作者：
GORBSKY, GJ
十年前，动粒通常被认为是相当无趣的结构，它只负责将有丝分裂染色体附着在微管上。然而，在过去的几年里，许多实验证明了这一观点是错误的，并证明动粒积极参与了染色体沿着有丝分裂纺锤体微管的运动。现在看来，除了运动功能外，动粒还作为动态和适应性中心，通过有丝分裂调节细胞周期进程。
A decade ago, kinetochores were generally regarded as rather unintersting structures that served only to attach mitotic chromosomes to microtubules. In the past few years, however, a number of experiments have belied this view and demonstrated that kinetochores are actively involved in moving chromosomes along the microtubules of the mitotic spindle. Now it appears that in addition to their function in motility, kinetochores act as dynamic and adaptable centres for regulating cell cycle progression through mitosis.