Catecholamine excretion and circadian blood pressure profile in patients with pheochromocytoma
Catecholamine excretion and circadian blood pressure profile in patients with pheochromocytoma
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DOI：
10.1196/annals.1353.008
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发表时间：
2006-01-01
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影响因子：
--
通讯作者：
Gaciong, Zbigniew
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文献类型：
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作者：
Dabrowska, Elzbieta;Lewandowski, Jacek;Gaciong, Zbigniew
继发性高血压患者的昼夜血压（BP）节律经常受到干扰。本文的目的是研究35例嗜铬细胞瘤患者（平均年龄42 - 19岁）昼夜节律血压谱参数的变化，采用傅立叶分析两步统计方法与昼夜尿儿茶酚胺排泄有关。24小时动态血压测量（ABPM）使用SpaceLabs 90,207监测仪。所有患者均采集白天和夜间尿液，以确定昼夜节律儿茶酚胺排泄情况。应用傅里叶分析估计ABPM的血压昼夜节律，包括最高（Max）和最低（Min）收缩压（SBP）和舒张压（DBP）血压值，norad （ampSBP, ampDBP）和早期峰期（APSBP， APDBIP）。血压昼夜节律的傅里叶指数为：MaxSBP 153 +/- 28 mm Hg， MaxDBP 99 +/- 16 μ g, MinSBP 117 +/- 17 mm Hg, MinDBP 69 +/- 11 mm Fig, ampSBP 18 +/- 8 mm Hg, ampDBP 14 +/- 5 mm Hg, APSBP 10 +/- 5 (h), APDBP 11 +/- 3 (h)。白天(d)和夜间(n)尿去甲肾上腺素（NA）、肾上腺素(A)和多巴胺（DA）排泄量分别为：dNA 103.5 +/- 89.8 mu g/14 h, nNA 52 +/- 70.8 mu g/10 h, DA 13.2 +/- 17.9 mu g/14 h；nA 6.13 +/- 9.6 ULg/10 h, dD 181.8 +/- 87.3 mu g/14 h, nD 89.3 +/- 59.8 mu g/10 h。尿dNa排泄量与MaxDBP呈正相关（r = 0.37, P < 0.05），尿nNA和尿dA排泄量与APDBP呈正相关（r = 0.47, r = 0.35， P均< 0.05）。因此，肿瘤释放的儿茶酚胺除了影响24小时平均血压值外，还可能扰乱嗜铬细胞瘤患者的昼夜血压节律。
Circadian blood pressure (BP) rhythm is often disturbed in patients with secondary forms of hypertension. The aim of the present article was to investigate changes in circadian BP profile parameters using two-step statistical approach by Fourier analysis in relation to day and night urinary catecholamine excretion in 35 patients with pheochromocytoma (mean age 42 19 years). Twenty-four-hour ambulatory BP measurements (ABPM) were obtained using the SpaceLabs 90,207 monitor. Daytime and night-time urine collection was obtained in all patients to determine circadian catecholamine excretion. Fourier analysis was applied to estimate measures of BP cireadian rhythm in ABPM, including the highest (Max) and lowest (Min) systolic (SBP) and diastolic (DBP) BP values, norad (ampSBP, ampDBP), and early acrophase (APSBP, APDBIP). The Fourier indices of circadian BP rhythm were: MaxSBP 153 +/- 28 mm Hg, MaxDBP 99 +/- 16 nun Ug, MinSBP 117 +/- 17 mm Hg, MinDBP 69 +/- 11 mm Fig, ampSBP 18 +/- 8 mm Hg, ampDBP 14 +/- 5 mm Hg, APSBP 10 +/- 5 (h), and APDBP 11 +/- 3 (h). Urine noradrenaline (NA), adrenaline (A), and dopamine (DA) excretion during the day (d) and night (n) were: dNA 103.5 +/- 89.8 mu g/14 h, nNA 52 +/- 70.8 mu g/10 h, dA 13.2 +/- 17.9 mu g/14 h; nA 6.13 +/- 9.6 ULg/10 h, dD 181.8 +/- 87.3 mu g/14 h, and nD 89.3 +/- 59.8 mu g/10 h. A positive correlation was observed between urine dNa excretion and MaxDBP (r = 0.37, P < 0.05), and urine nNA and urine dA excretion were correlated with APDBP (r = 0.47, r = 0.35, respectively, both P < 0.05). Thus, in addition to the effect on mean 24-h BP values, catecholamines released by tumor may also disturb circadian BP rhythm in patients with pheochromocytoma.