Ocular manifestations of acquired immune deficiency syndrome.

Ocular manifestations of acquired immune deficiency syndrome.
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DOI：
10.1016/s0161-6420(89)32794-1
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发表时间：
1989-07
期刊：
Ophthalmology
影响因子：
13.7
通讯作者：
D. Jabs;W. Green;Robin Fox;B. Polk;J. Bartlett
D. Jabs;W. Green;Robin Fox;B. Polk;J. Bartlett
中科院分区：
医学1区
文献类型：
--
作者：
D. Jabs;W. Green;Robin Fox;B. Polk;J. Bartlett

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获得性免疫缺陷综合征（AIDS）的眼部并发症包括：（1）非感染性微血管病，最常见于视网膜，由棉絮状斑点组成，伴有或不伴有视网膜内血管病变和其他微血管异常;（2）机会性眼部感染，主要是巨细胞病毒（CMV）视网膜炎;（3）艾滋病患者中所见的肿瘤累及结膜、眼睑或眼眶（即，Kaposi肉瘤和淋巴瘤）;和（4）神经眼科病变。在一系列的200例艾滋病患者的临床评价，艾滋病视网膜病变存在于66.5%。64%的人有棉絮斑，12%的人有视网膜内出血。28%的艾滋病患者被诊断为巨细胞病毒性视网膜炎。在所有艾滋病患者中发现了8%的神经眼科病变，在隐球菌脑膜炎患者中发现了33%。经病理学评估，35例艾滋病相关综合征（ARC）患者中有40%存在获得性免疫缺陷综合征视网膜病变，232例无症状人类免疫缺陷病毒（HIV）感染患者中有1.3%存在获得性免疫缺陷综合征视网膜病变。这些结果表明，艾滋病视网膜病变的患病率随着艾滋病病毒感染的严重程度增加而增加，CMV视网膜炎在艾滋病患者中是一个严重的视力威胁问题。
The ocular complications of acquired immune deficiency syndrome (AIDS) include: (1) a noninfectious microangiopathy, most often seen in the retina, consisting of cotton-wool spots with or without intraretinal hemorrhages and other microvascular abnormalities; (2) opportunistic ocular infections, primarily cytomegalovirus (CMV) retinitis; (3) conjunctival, eyelid, or orbital involvement by those neoplasms seen in patients with AIDS (i.e., Kaposi's sarcoma and lymphoma); and (4) neuro-ophthalmic lesions. In a series of 200 AIDS patients evaluated clinically, AIDS retinopathy was present in 66.5%. Sixty-four percent had cotton-wool spots, and 12% had intraretinal hemorrhages. Cytomegalovirus retinitis was diagnosed in 28% of AIDS patients. Neuro-ophthalmic lesions were found in 8% of all AIDS patients and were present in 33% of those patients with cryptococcal meningitis. Acquired immune deficiency syndrome retinopathy was present in 40% of 35 patients with the AIDS-related complex (ARC) and in 1.3% of 232 patients with asymptomatic human immunodeficiency virus (HIV) infection, evaluated photographically. These results suggest that the prevalence of AIDS retinopathy increases with increasing severity of HIV infection, and that CMV retinitis presents a significant vision-threatening problem in AIDS patients.