Anemia and Functional Disability in Older Adults With Cancer.
Anemia and Functional Disability in Older Adults With Cancer.
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DOI：
10.6004/jnccn.2015.0152
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
Cancer and Aging Research Group (CARG)
中科院分区：
文献类型：
--
作者：
Owusu C;Cohen HJ;Feng T;Tew W;Mohile SG;Klepin HD;Gross CP;Gajra A;Lichtman SM;Hurria A;Cancer and Aging Research Group (CARG)
Anemia is associated with functional disability among older adults in general. However, the relationship between anemia and functional disability has not been well characterized among older adults with cancer. Therefore, we examined the association between anemia and functional disability in patients ≥ age 65 with cancer. We conducted cross-sectional analysis of data derived from a multi-center prospective study of 500 cancer patients aged ≥ 65 years. The primary outcome was functional disability at chemotherapy initiation, defined as the need for assistance with at least one instrumental activity of daily living. Anemia (World Health Organization criteria) was defined as hemoglobin (Hb) <12g/dl (women) and Hb <13g/dl (men). Multivariable logistic regression was used to examine the association between anemia and functional disability. Among 491 evaluable patients [median age 73.1 years (range 65-91), the prevalence of functional disability and anemia was 43% and 51%, respectively. Compared with patients without anemia, patients with anemia were more likely to report functional disability. On multivariable analysis, adjusting for sex, stage and unintentional weight loss, patients with anemia were more likely to have functional disability, [Odds Ratio = 2.40, 95% confidence interval = 1.61-3.59]. Anemia was highly prevalent and independently associated with functional disability in this cohort of older adults with cancer. Given the importance of functional status in cancer treatment decision-making, longitudinal studies evaluating the causal relation between anemia and functional status among older cancer patients are warranted to evaluate causality.
