Facile deprotection of dithioacetals by using a novel 1,4-benzoquinone/cat. NaI system
Facile deprotection of dithioacetals by using a novel 1,4-benzoquinone/cat. NaI system
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DOI：
10.1016/j.tet.2013.08.061
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发表时间：
2013-11-04
期刊：
影响因子：
2.1
通讯作者：
Kondo, Yoshinori
中科院分区：
文献类型：
--
作者：
Inamoto, Kiyofumi;Yamada, Tetsuya;Kondo, Yoshinori
1，4-苯二酚与催化量NaI的组合被发现对二硫代缩醛的脱保护是有效的。这些反应在温和的近中性反应条件下有效地进行，生成了广泛的芳基和烷基醛和酮，总收率高，官能团相容性好。因此，开发的方法代表了一种通用的、简便的、高度适用的脱保护二硫代缩醛的方法。(C)2013爱思唯尔有限公司。保留所有权利。
The combination of 1,4-benzoquinone and a catalytic amount of NaI was found to be effective for the deprotection of dithioacetals. The reactions proceeded efficiently under mild, near-neutral reaction conditions, producing a wide range of aryl and alkyl aldehydes and ketones generally in high yields with good functional group compatibility. The method developed therefore represents a general, facile, and highly applicable approach for deprotecting dithioacetals. (C) 2013 Elsevier Ltd. All rights reserved.