Epithelial ovarian cancer risk by invasiveness and cell type in the Central Valley of California
Epithelial ovarian cancer risk by invasiveness and cell type in the Central Valley of California
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DOI：
10.1016/j.ygyno.2004.07.012
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发表时间：
2004-10-01
影响因子：
4.7
通讯作者：
Cress, RD
中科院分区：
文献类型：
--
作者：
Mills, PK;Riordan, DG;Cress, RD
目标。目的：从卵巢上皮癌的侵袭性水平和组织学角度评价卵巢上皮癌的危险因素。在加利福尼亚州中部的22个县进行了为期两年(2000年1月至2001年12月)的以人群为基础的平等机会流行病学病例对照研究，这些县构成了两个区域癌症登记的报告区。电话访谈的256个病例和1122个对照频率在年龄和种族上匹配。访谈获得了有关人口统计学因素的信息，以及与受访者的月经和生殖经历、外源性激素使用、手术史和癌症家族史相关的信息。调整后的优势比用分层和Logistic回归方法计算。按侵袭程度和细胞类型进行分析。使用口服避孕药和产次之间存在很强的保护性关联。风险随着卵巢家族史的增加而增加，但与乳腺癌无关，而且初次出生的年龄与风险的增加呈正相关。激素替代疗法只在长期使用者中与风险增加相关。许多关系仅在特定的组织学亚型中观察到。EOC的风险与几种生活方式和环境暴露有关，但这些影响的影响似乎取决于EOC的侵袭性水平和组织学亚型。然而，可供分析的样本大小限制了我们的统计能力和我们按组织学亚型分析数据的能力，从而限制了对我们结果的解释。(C)2004 Elsevier Inc.保留所有权利。
Objective. To evaluate epithelial ovarian cancer (EOC) risk factors by level of invasiveness and histology.Methods. A population-based epidemiologic case-control study of EOC was conducted over a 2-year period (January 2000 to December 2001) in 22 counties of Central California that comprise the reporting area for two regional cancer registries. Telephone inter-views were conducted with 256 cases and 1122 control frequencies matched on age and ethnicity. The interview obtained information on demographic factors as well as information pertinent to the respondent's menstrual and reproductive experience, use of exogenous hormones, surgical history, and family history of cancer. Adjusted odds ratios were calculated using stratification as well as Logistic regression methods. Analyses were completed by level of invasiveness and cell type.Results. Strong protective associations were observed for use of oral contraceptives and parity. Risk increased with a family history of ovarian, but not breast cancer and age at first birth was positively associated with increased risk. Hormone replacement therapy was associated with increased risk only in long-term users. Many of the relationships were observed only in specific histologic subtypes of EOC.Conclusion. Risk of EOC is associated with several lifestyle and environmental exposures but the impact of these effects appears to be dependent upon level of invasiveness and histologic subtypes of EOC. However, the sample size available for analysis limits our statistical power and our ability to analyze data by histologic subtype, thus limiting interpretation of our results. (C) 2004 Elsevier Inc. All rights reserved.