Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography
Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography
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DOI：
10.1117/1.jbo.17.7.076012
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发表时间：
2012-07-01
影响因子：
3.5
通讯作者：
Wang, Lihong V.
中科院分区：
文献类型：
--
作者：
Chatni, Muhammad Rameez;Xia, Jun;Wang, Lihong V.
随着小动物在人类疾病研究中的应用越来越广泛，小动物全身分子成像在生物医学研究中发挥着重要作用。目前，没有一种现有的成像模式可以同时提供解剖学和葡萄糖分子信息，导致构建双模式系统的成本更高。即使利用图像配准，分子成像模态的空间分辨率也没有提高。利用环形共聚焦光声计算机断层扫描系统，我们证明，第一次，解剖结构和葡萄糖摄取可以成像在一个单一的模式。使用内源性血红蛋白对比剂对解剖结构进行成像，使用近红外染料标记的2-脱氧葡萄糖对葡萄糖代谢进行成像。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.7.076012]
With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.076012]