AGE-RELATED-CHANGES IN HUMORAL AND CELL-MEDIATED-IMMUNITY IN DOWN-SYNDROME CHILDREN LIVING AT HOME
AGE-RELATED-CHANGES IN HUMORAL AND CELL-MEDIATED-IMMUNITY IN DOWN-SYNDROME CHILDREN LIVING AT HOME
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DOI：
10.1203/00006450-198711000-00013
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发表时间：
1987-11-01
影响因子：
3.6
通讯作者：
QUIGLEY, G
中科院分区：
文献类型：
--
作者：
LOCKITCH, G;SINGH, VK;QUIGLEY, G
在唐氏综合征中，体液和细胞介导的免疫功能缺失已被描述，但报道的结果不一致。混杂因素包括年龄、机构与家庭生活、B型肝炎抗原血症和锌缺乏。为了澄清这个问题，我们研究了64名唐氏综合症（DS）儿童，并与年龄匹配的对照组进行了比较。所有的孩子都一直住在家里。所有DS患儿均为B型肝炎表面抗原阴性。DS组的血清锌浓度平均比年龄匹配的对照儿童低12 μ g/dl。他们的免疫球蛋白M、总淋巴细胞计数、T和B淋巴细胞以及T辅助细胞和抑制细胞水平也显著降低。在体外淋巴细胞对植物血凝素和刀豆球蛋白A的反应显着降低，在所有年龄的DS组。淋巴细胞反应美洲商陆丝裂原随年龄增加，在对照组儿童，但下降的DS儿童。到18岁时，DS的平均反应比对照组低60，000 cpm。DS组的免疫球蛋白A和G浓度显著高于对照组，且差异随年龄增加而增加。补体成分C3和C3也较高的DS组在所有年龄。DS组各年龄组HNK-1阳性细胞数均高于对照组。当排除肝炎和制度化作为混杂因素时，DS儿童在体液和细胞介导的免疫方面与年龄匹配的对照组仍然存在差异。
Abnormalities of humoral and cell-mediated immunity have been described in Down syndrome but reported findings have been inconsistent. Confounding factors have included age, institutional versus home life, hepatitis B antigenemia, and zinc deficiency. To clarify this problem, we studied 64 children with Down syndrome (DS) compared with an age-matched control group. All children had always lived at home. All the DS children were negative for hepatitis B surface antigen. Serum zinc concentration in the DS group was on average 12 .mu.g/dl lower than age-matched control children. They also had significantly lower levels of immunoglobulin M, total lymphocyte count, T and B lymphocytes, and T helper and suppressor cells. In vitro lymphocyte response to phytohemagglutinin and concanavalin A was significantly reduced at all ages in the DS group. Lymphocyte response to pokeweed mitogen increased with age in control children but decreased in the DS children. By 18 yr, the mean response of DS was 60,000 cpm lower than controls. The DS group had significantly higher concentrations of immunoglobulins A and G than controls and the difference increased with age. Complement fractions C3 and C3 were also higher in the DS group at all ages. The number of HNK-1 postiive cells was higher in the DS group than controls at all ages. When hepatitis and institutionalization are excluded as confounding factors, DS children still differ in both humoral and cell-mediated immunity from an age-matched control group.