Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function
Cutting Edge: Memory CD8 T Cell Compartment Grows in Size with Immunological Experience but Nevertheless Can Lose Function
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DOI：
10.4049/jimmunol.0902454
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发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Busch, Dirk H.
中科院分区：
文献类型：
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作者：
Huster, Katharina M.;Stemberger, Christian;Busch, Dirk H.
适应性免疫系统的大小被认为是通过预先存在的记忆的消耗来保持恒定的。然而，最近的研究表明，CD8 记忆区室的大小可以增长，并且预先存在的记忆的数量在很大程度上得以保留，预测预先存在的免疫力应该得到维持（Vezys 等人；Nature 457：196-199）。这一假设仍缺乏实验证明。我们在单核细胞增生李斯特菌 (L. m.) 感染模型中解决了这个问题，并通过随后接种改良的痘苗病毒安卡拉来确认记忆区室大小的增长。我们还发现，先前存在的 L.m. 特异性记忆 CD8 T 细胞仅有适度的损耗。然而，预先存在的针对 L.m. 的保护性免疫力。未保存。与中央记忆细胞相比，预先存在的 L.m. 特异性效应记忆细胞会发生改变，这会导致预先存在的保护性免疫力显着丧失。我们的研究结果与引入大量新 CD 记忆细胞的疫苗具有临床相关性，因为这可能会影响预先存在的免疫力。免疫学杂志，2009，183：6898-6902。
The size of the adaptive immune system is considered to be kept constant by the attrition of pre-existing memory. However, recently it was shown that the CD8 memory compartment can grow in size and the number of pre-existing memory is largely preserved, predicting that pre-existing immunity should be maintained (Vezys et al.; Nature 457: 196-199). Experimental proof for this assumption is still lacking. We address this question in the Listeria monocytogenes (L. m.) infection model and confirm the growth of size of the memory compartment by subsequent vaccination with modified vaccinia virus Ankara. We also find only modest attrition of pre-existing L.m.-specific memory CD8 T cells. However, preexisting protective immunity toward L.m. is not preserved. Pre-existing L.m.-specific effector-memory cells, in contrast to central memory cells, become altered, and this results in a significant loss of pre-existing protective immunity. Our findings are clinically relevant for vaccines introducing new CD memory cells in high numbers, as this might influence pre-existing immunity. The Journal of Immunology, 2009, 183: 6898-6902.