Salicylate and mitochondrial injury in Reye's syndrome.
Salicylate and mitochondrial injury in Reye's syndrome.
复制标题
雷氏综合征中的水杨酸盐和线粒体损伤。
作者：
K. You
电镜和分光光度研究表明，水杨酸盐在等渗盐溶液中引起线粒体的明显肿胀。在整体形态上，水杨酸处理的线粒体与雷氏综合征患者的线粒体相似。水杨酸类似物，如间羟基苯甲酸酯、对羟基苯甲酸酯和苯甲酸酯没有这种作用。被水杨酸盐变形的线粒体在去除药物后倾向于恢复到原来的浓缩形式。
Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.