Addition of Supervised Exercise Training to a Post-Hospital Disease Management Program for Patients Recently Hospitalized With Acute Heart Failure The EJECTION-HF Randomized Phase 4 Trial
Addition of Supervised Exercise Training to a Post-Hospital Disease Management Program for Patients Recently Hospitalized With Acute Heart Failure The EJECTION-HF Randomized Phase 4 Trial
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DOI：
10.1016/j.jchf.2017.11.016
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发表时间：
2018-02-01
影响因子：
13
通讯作者：
O'Rourke, Peter
中科院分区：
文献类型：
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作者：
Mudge, Alison M.;Denaro, Charles P.;O'Rourke, Peter
目的：本研究旨在衡量近期急性心力衰竭（HF）住院患者在疾病管理方案中加入中心运动训练（ET）对全因死亡或再入院的影响。背景：推荐对心衰患者进行ET治疗，但证据主要基于ET作为稳定门诊患者的单一干预。方法：采用盲法结局评估的随机对照试验，纳入澳大利亚昆士兰州5家医院的成年HF出院患者。所有参与者都接受了hf疾病管理计划和支持的家庭锻炼计划；干预参与者接受24周有监督的以中心为基础的ET治疗。主要结局是12个月的全因死亡或再入院。预先计划的亚组包括年龄为70岁，女性71例（25.5%），左室射血分数为bb0 40%的患者62例（23.3%）。没有与ET相关的不良事件。两组间的主要结局没有差异（140例干预中有84例[60.0%]，对照组有138例[65.2%],p = 0.37），但在参与者年龄上有更大获益的趋势
OBJECTIVES This study sought to measure the impact on all-cause death or readmission of adding center-based exercise training (ET) to disease management programs for patients with a recent acute heart failure (HF) hospitalization.BACKGROUND ET is recommended for patients with HF, but evidence is based mainly on ET as a single intervention in stable outpatients.METHODS A randomized, controlled trial with blinded outcome assessor, enrolling adult participants with HF discharged from 5 hospitals in Queensland, Australia. All participants received HF-disease management program plus supported home exercise program; intervention participants were offered 24 weeks of supervised center-based ET. Primary outcome was all-cause 12-month death or readmission. Pre-planned subgroups included age (= 70 years, 71 (25.5%) females, and 62 (23.3%) with a left ventricular ejection fraction of >40%. There were no adverse events associated with ET. There was no difference in primary outcome between groups (84 of 140 [60.0%] intervention vs. 90 of 138 [65.2%] control; p = 0.37), but a trend toward greater benefit in participants age