Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation.
Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation.
复制标题
DOI：
10.3390/toxins8020034
复制
发表时间：
2016-01-22
期刊：
影响因子：
4.2
通讯作者：
Jacquez P
中科院分区：
文献类型：
--
作者：
Sun J;Jacquez P
细菌毒素与细胞表面受体之间的相互作用是宿主-病原体相互作用的重要组成部分。炭疽毒素保护性抗原（PA）与细胞表面受体结合，通过受体介导的内吞作用进入细胞，并在内体膜上形成孔，将毒素酶易位到宿主细胞的胞质溶胶中。炭疽毒素受体2（anthrax toxin receptor 2，ANTXR 2）是炭疽毒素在体内的主要受体，在炭疽毒素的作用中起重要作用，它为炭疽毒素提供了一个高亲和力的结合锚和进入宿主细胞的途径。ANTXR 2还通过将PA孔形成的pH阈值转移到更酸性的pH范围来充当分子钳，这防止在毒素到达指定的细胞内位置之前在中性pH下过早形成孔。最近的研究表明，ANTXR 2的免疫球蛋白（IG）样结构域中的二硫键在炭疽毒素作用中起着重要作用。在这里，我们将回顾ANTXR 2在炭疽毒素作用中的作用，重点是最新的知识。
Interaction between bacterial toxins and cellular surface receptors is an important component of the host-pathogen interaction. Anthrax toxin protective antigen (PA) binds to the cell surface receptor, enters the cell through receptor-mediated endocytosis, and forms a pore on the endosomal membrane that translocates toxin enzymes into the cytosol of the host cell. As the major receptor for anthrax toxin in vivo, anthrax toxin receptor 2 (ANTXR2) plays an essential role in anthrax toxin action by providing the toxin with a high-affinity binding anchor on the cell membrane and a path of entry into the host cell. ANTXR2 also acts as a molecular clamp by shifting the pH threshold of PA pore formation to a more acidic pH range, which prevents premature pore formation at neutral pH before the toxin reaches the designated intracellular location. Most recent studies have suggested that the disulfide bond in the immunoglobulin (Ig)-like domain of ANTXR2 plays an essential role in anthrax toxin action. Here we will review the roles of ANTXR2 in anthrax toxin action, with an emphasis on newly updated knowledge.
保护性抗原突变增加了炭疽毒素受体2介导的孔形成的pH阈值。
影响因子：
2.9
作者：
Dennis MK;Mogridge J
通讯作者：
Mogridge J