Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers.
Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers.
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吸烟者和非吸烟者的纹状体多巴胺D2/D3受体可用性的性别差异。
DOI：
10.1017/s1461145711001957
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
London ED
中科院分区：
文献类型：
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作者：
Brown AK;Mandelkern MA;Farahi J;Robertson C;Ghahremani DG;Sumerel B;Moallem N;London ED
在之前的研究中，尼古丁依赖的男性比不吸烟者表现出更低的壳核D2/D3多巴胺受体的可用性，但在女性中没有进行类似的评估。使用正电子发射断层扫描[18F]fallypride测试了女性和男性（19名轻度吸烟者，18名不吸烟者）纹状体D2/D3多巴胺受体可用性的性别和吸烟差异。在纹状体体积和全脑体素分析中，使用参考区域方法确定受体可用性。在尾状核和壳核中观察到显著的吸烟性别相互作用。事后t检验显示，男性吸烟者D2/D3多巴胺受体的可用性明显低于女性吸烟者（- 17%尾状核，- 21%壳核）和男性不吸烟者（- 15%尾状核，- 16%壳核）。女性吸烟者与不吸烟者没有区别。全脑分析显示没有统计学意义的体素或簇。这些结果表明，低受体可用性可能导致尼古丁依赖的脆弱性，或者吸烟选择性地影响男性而不是女性D2/D3受体的下调。
In previous research, nicotine-dependent men exhibited lower putamen D2/D3 dopamine-receptor availability than nonsmokers, but parallel assessments were not performed in women. Women and men (19 light smokers, 18 nonsmokers) were tested for differences due to sex and smoking in striatal D2/D3 dopamine-receptor availability, using positron emission tomography with [18F]fallypride. Receptor availability was determined using a reference region method, in striatal volumes and in whole-brain, voxel-wise analysis. Significant sex-by-smoking interactions were observed in the caudate nuclei and putamen. Post hoc t-tests showed that male smokers had significantly lower D2/D3 dopamine-receptor availability than female smokers (−17% caudate, −21% putamen) and male nonsmokers (−15% caudate, −16% putamen). Female smokers did not differ from nonsmokers. Whole-brain analysis demonstrated no statistically significant voxels or clusters. These results suggest that low receptor availability may confer vulnerability to nicotine dependence or that smoking selectively affects D2/D3 receptor down-regulation in men but not women.