Porphyrin-based nanocomposites for tumor photodynamic therapy
Porphyrin-based nanocomposites for tumor photodynamic therapy
复制标题
用于肿瘤光动力治疗的卟啉基纳米复合材料
DOI：
10.1557/mrs.2019.42
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发表时间：
2019
期刊：
影响因子：
5
通讯作者：
Zhang Bingbo
中科院分区：
文献类型：
--
作者：
Yang Weitao;Zhang Bingbo
卟啉及其相关衍生物已被广泛用作肿瘤光动力治疗（PDT）的光敏剂。为了克服卟啉类光敏剂在光动力治疗中的局限性，卟啉与纳米技术的结合为提高卟啉类光动力治疗的有效性和安全性提供了新的视角。迄今为止，已经开发了各种有机和无机纳米颗粒用于高有效载荷光敏剂的卟啉递送、防止光敏剂过早释放和肿瘤选择性靶向。本文综述了卟啉类光敏剂的制备方法，包括包封、共价结合、光动力学自组装以及单线态氧的表征方法。我们集中在总结的策略，提高癌症PDT疗效的纳米技术。最后，探讨了卟啉基纳米复合材料介导的光动力学治疗的挑战和前景。
Porphyrins and their associated derivatives have been widely used as photosensitizers for photodynamic therapy (PDT) of tumors. To overcome the limitations of porphyrin photosensitizers in PDT, the marriage of porphyrins and nanotechnology offers a new perspective to improve the efficacy and safety of porphyrin-based PDT. To date, various organic and inorganic nanoparticles have been developed for porphyrin delivery for high payload photosensitizers, protection from premature release of photosensitizers, and tumor-selective targeting. In this article, we summarize the strategies for porphyrin photosensitizer delivery, including encapsulation, covalent conjugation, self-assembly for PDT, and characterization methods of singlet oxygen (^1O_2) generation. We focus on the summarized strategies of improving cancer PDT efficacy by nanotechnology. Finally, the challenges and outlook for porphyrin-based nanocomposites-mediated PDT are discussed.