Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress
Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress
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DOI：
10.1016/s0024-3205(02)01522-9
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发表时间：
2002-04-21
期刊：
影响因子：
6.1
通讯作者：
Tanaka, T
中科院分区：
文献类型：
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作者：
Kurihara, H;Koda, H;Tanaka, T
我们研究了虾青素对小鼠自然杀伤（NK）细胞抗肿瘤效应活性的影响，以确定虾青素（ASX）与束缚应激治疗相结合时的免疫学意义。当小鼠仅用束缚应激处理时，脾细胞总数和每个脾的NK细胞活性水平在第3天降至最低点。应激还引起肝组织脂质过氧化反应显著增加。ASX（100 mg/kg/天，p.o.，4 d），改善束缚应激所致的免疫功能紊乱。另一方面，在接种P815肥大细胞瘤细胞后第12天，在同系DBA/2小鼠的肝脏中观察到转移性结节。在P815接种前第3天施加束缚应激进一步促进肝转移。每日口服施用ASX（lmg/kg/天，p.o.，14 d）明显减弱束缚应激对小鼠肝转移的促进作用。这些结果表明，虾青素通过抑制应激诱导的脂质过氧化反应来提高抗肿瘤免疫应答。(C)2002年爱思唯尔科技有限公司All rights reserved.
We investigated the effects of astaxanthin on the antitumor effector activity of natural killer (NK) cells suppressed by stress in mice in order to define the immunological significance of astaxanthin (ASX) when combined with restraint stress treatment. When the mice were treated with restraint stress alone, the total number of spleen cells, and the level NK cell activity per spleen were reduced to a nadir on day 3. The stress also caused a significant increase in the lipid peroxidation of liver tissue. ASX (100 mg/kg/day, p.o., 4 days) improved the immunological dysfunction induced by restraint stress. On the other hand, metastatic nodules were observed in the livers of syngenic DBA/2 mice on day 12 after inoculation of P815 mastocytoma cells. Hepatic metastasis was promoted further by restraint stress when applied on day 3 before the inoculation of P815. Daily oral administration of ASX (1 mg/kg/day, p.o., 14 days) markedly attenuated the promotion of hepatic metastasis induced by restraint stress. These results suggested that astaxanthin improves antitumor immune responses by inhibiting of lipid peroxidation induced by stress. (C) 2002 Elsevier Science Inc. All rights reserved.