Cerebral microbleeds - Prevalence and associations with cardiovascular risk factors in the Framingham Study
Cerebral microbleeds - Prevalence and associations with cardiovascular risk factors in the Framingham Study
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DOI：
10.1161/01.str.0000131809.35202.1b
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发表时间：
2004-08-01
期刊：
影响因子：
8.3
通讯作者：
DeCarli, C
中科院分区：
文献类型：
--
作者：
Jeerakathil, T;Wolf, PA;DeCarli, C
背景和目的-脑微出血（CMB）是梯度回波T2* 加权磁共振成像（T2*MRI）上的低信号强度区域，对应于血管周围空间的含铁血黄素沉积。动脉粥样硬化或淀粉样血管病引起的微血管病变可能导致这些病变的形成;因此，CMB与心血管危险因素、APOE等位基因状态和脑形态学之间可能存在相关性。我们在FHS研究（FHS）中检查了这些关系。方法：在FHS后代和队列的472例受试者中，我们将CMB状态与年龄、性别、收缩压、总胆固醇和高密度脂蛋白胆固醇（HDL-C）水平、吸烟、糖尿病、总半球脑体积、白色高信号体积（WMHV）和APOE等位基因状态相关。结果：CMB的总体患病率为4.7%，年龄越大，男性发病率越高。血压、脑容量和WMHV在粗分析中与CMB相关，但在调整年龄和性别后则无关。有没有显着的关系表现出之间的CMB和APOE等位基因状态，胆固醇，吸烟，或diabetes. Conclusions，有一个低患病率的CMB在社区和一个强有力的关系，随着年龄的增长和男性性别。我们没有发现与心血管危险因素，APOE状态，脑容量或WMH的独立关系。
Background and Purpose-Cerebral microbleeds (CMBs) are areas of low signal intensity on gradient echo T2*-weighted magnetic resonance imaging (T2*MRI) corresponding to hemosiderin deposits in the perivascular space. Microangiopathy from atherosclerosis or amyloid angiopathy might lead to the formation of these lesions; therefore, there may be associations between CMBs and cardiovascular risk factors, APOE allele status, and brain morphology. We examined these relationships in the Framingham Study (FHS).Methods-In 472 subjects from the FHS Offspring and Cohort, we related CMB status to age, sex, systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels, smoking, diabetes, total hemispheric brain volume, white matter hyperintensity volume (WMHV), and APOE allele status.Results-Overall prevalence of CMBs was 4.7%, but CMBs were more prevalent with advanced age and male sex. Blood pressure, brain volume, and WMHV were related to CMBs in crude analysis but not after adjustment for age and sex. There were no significant relationships demonstrated between CMBs and APOE allele status, cholesterol, smoking, or diabetes.Conclusions-There is a low prevalence of CMBs in the community and a strong relationship with increasing age and male sex. We found no independent relationships with cardiovascular risk factors, APOE status, brain volumes, or WMH.