PET/CT imaging-guided dose painting in radiation therapy.
PET/CT imaging-guided dose painting in radiation therapy.
复制标题
DOI：
10.1016/j.canlet.2014.07.042
复制
发表时间：
2014-12
期刊：
影响因子：
9.7
通讯作者：
Xiaorong Shi;Xue Meng;Xin-dong Sun;L. Xing;Jinming Yu
中科院分区：
文献类型：
--
作者：
Xiaorong Shi;Xue Meng;Xin-dong Sun;L. Xing;Jinming Yu
随着新模式和新技术的发展，功能成像在放射治疗中的应用正在迅速扩大。PET功能成像结合RT为剂量涂绘的临床应用提供了新的途径——一种新的RT策略，根据功能成像信息提供优化的剂量再分配，进一步改善肿瘤控制。介绍了两种典型的剂量绘制策略：等高线剂量绘制（DPBC）和数字剂量绘制（DPBN）。DPBN设置了同一体素的增强剂量和图像强度的线性相关，而均匀剂量则给予DPBC中PET图像中创建的阈值轮廓的子体积。两者都符合严格的危险器官（OAR）限制，是临床实践中提高亚容量的替代方案。本文综述了将PET成像纳入RT治疗计划的基本原理、靶点验证、剂量处方验证与评价以及近期临床进展。为了深入研究其临床应用中尚未解决的问题，有必要进行进一步的研究。
Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting – a new RT strategy delivering optimized dose redistribution according to the functional imaging information to further improve tumour control. Two prototypical strategies of dose painting are reviewed: dose painting by contours (DPBC) and dose painting by numbers (DPBN). DPBN set a linear correlation of the boost dose and image intensity of this same voxel while homogeneous dose is given to the subvolume contoured by a threshold created in PET images in DPBC. Both comply with strict organs at risk (OAR) constraints and are alternatives for boosting subvolumes in clinical practice. This review focuses on the rationale, target validation, dose prescription verification and evaluation and recent clinical achievements in the field of integrating PET imaging into RT treatment planning. Further research is necessary in order to investigate unresolved problems in its routine clinical application thoroughly.