Possible dual roles for prostacyclin in human pregnancy and labor.
Possible dual roles for prostacyclin in human pregnancy and labor.
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DOI：
10.1172/jci37785
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发表时间：
2008-12
期刊：
影响因子：
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通讯作者：
Michael J. Taggart;G. Nicholas Europe-Finner;Bryan F. Mitchell
中科院分区：
文献类型：
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作者：
Michael J. Taggart;G. Nicholas Europe-Finner;Bryan F. Mitchell
在怀孕期间，子宫壁的肌肉层称为子宫肌层，主要由平滑肌细胞组成，保持在相对静止的状态。在分娩过程中建立子宫收缩需要从子宫肌层静止到子宫肌层激活的转换。研究人员长期以来一直困惑于这样一个事实：临产前子宫产生的主要前列腺素前列环素是一种平滑肌松弛剂。在这一期的JCI中，Fetalvero等人提供了他们提出的数据，至少部分解释了这一悖论（见3966页开始的相关文章）。作者检查了近期孕妇的子宫组织，发现前列环素刺激可以提高cAMP水平，而以前认为cAMP水平只影响子宫肌层静止，随着时间的推移，前列环素刺激可以通过增加一组被认为是子宫收缩状态指示的选定蛋白质的表达来促进子宫肌层激活。
During pregnancy, the muscular layer of the uterine wall known as the myometrium, which is composed mainly of smooth muscle cells, is maintained in a state of relative quiescence. A switch from myometrial quiescence to myometrial activation is required to establish uterine contractions during labor. Researchers have long been perplexed by the fact that the major prostaglandin produced by the uterus just prior to labor, prostacyclin, is a smooth muscle relaxant. In this issue of the JCI, Fetalvero et al. provide data that they propose explains this paradox, at least in part (see the related article beginning on page 3966). The authors examined uterine tissue from pregnant women near term and found that prostacyclin stimulation, which raises cAMP levels that were previously thought to affect only myometrial quiescence, can promote myometrial activation over time by increasing the expression of a select group of proteins thought to be indicative of a uterine contractile state.