Nonthermal Irreversible Electroporation: Fundamentals, Applications, and Challenges
Nonthermal Irreversible Electroporation: Fundamentals, Applications, and Challenges
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DOI：
10.1109/tbme.2013.2238672
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发表时间：
2013-03-01
影响因子：
4.6
通讯作者：
Yarmush, Martin L.
中科院分区：
文献类型：
--
作者：
Golberg, Alexander;Yarmush, Martin L.
组织消融是治疗许多疾病的基本程序。在过去的十年里，一种使用强脉冲电场的非热组织消融术，被称为非热不可逆电穿孔(NTIRE)，已经迅速出现。然而，NTIRE导致细胞死亡的确切机制目前尚不清楚。然而，该技术具有显著的能力，可以消融大血管附近的组织，保留组织结构，缩短手术时间，缩短术后恢复期，迅速将NTIRE从长凳移到床边。这项工作提供了关于NTIRE的发展，其当前的艺术状态，挑战和未来需求的概述。
Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irreversible electroporation (NTIRE), has rapidly emerged. The exact mechanisms responsible for cell death by NTIRE, however, are currently unknown. Nevertheless, the technique's remarkable ability to ablate tissue in the proximity of larger blood vessels, to preserve tissue architecture, short procedure duration, and shortened postoperative recovery period rapidly moved NTIRE from bench to bed side. This work provides an overview on the development of NTIRE, its current state-of-the-art, challenges, and future needs.