The aftermath of 9/11: Effect of intensity and recency of trauma on outcome
The aftermath of 9/11: Effect of intensity and recency of trauma on outcome
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DOI：
10.1037/1528-3542.7.2.227
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发表时间：
2007-05-01
期刊：
影响因子：
4.2
通讯作者：
Temple, Elise
中科院分区：
文献类型：
--
作者：
Ganzel, Barbara;Casey, B. J.;Temple, Elise
创伤暴露对健康个体的大脑和行为有长期影响吗？作者使用功能性磁共振成像来评估2001年9月11日灾难对22名健康成年人杏仁核功能的影响。在恐怖袭击发生三年多后，与平静的面孔相比，在9/11事件中，在世界贸易中心1.5英里范围内的人的双侧杏仁核活动要高于那些居住在200英里以外的人（在扫描时，所有人都住在纽约大都市区）。这种活动介导了群体地位与创伤后应激障碍当前症状之间的关系。反过来，群体状态对杏仁核激活（恐惧与平静的面孔）和当前症状的影响可以通过一生中最严重创伤的时间和最严重创伤的强度进行统计学解释，如创伤时报告的症状所示。这些数据与高强度创伤暴露后杏仁核反应性升高的模型一致，恢复相对缓慢。
Does trauma exposure have a long-term impact on the brain and behavior of healthy individuals? The authors used functional magnetic resonance imaging to assess the impact of proximity to the disaster of September 11, 2001, on amygdala function in 22 healthy adults. More than three years after the terrorist attacks, bilateral amygdala activity in response to viewing fearful faces compared to calm ones was higher in people who were within 1.5 miles of the World Trade Center on 9/11, relative to those who were living more than 200 miles away (all were living in the New York metropolitan area at time of scan). This activity mediated the relationship between group status and current symptoms of posttraumatic stress disorder. In turn, the effect of group status on both amygdala activation (fearful vs. calm faces) and current symptoms was statistically explained by time since worst trauma in lifetime and intensity of worst trauma, as indicated by reported symptoms at time of the trauma. These data are consistent with a model of heightened amygdala reactivity following high-intensity trauma exposure, with relatively slow recovery.